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A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis).

A novel simian retrovirus subtype discovered in cynomolgus monkeys (Macaca fascicularis).
Author Information (click to view)

Zao CL, Tomanek L, Cooke A, Berger R, Yang L, Xie C, Chen S, Shi C, Rong R,


Zao CL, Tomanek L, Cooke A, Berger R, Yang L, Xie C, Chen S, Shi C, Rong R, (click to view)

Zao CL, Tomanek L, Cooke A, Berger R, Yang L, Xie C, Chen S, Shi C, Rong R,

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The Journal of general virology 2016 9 08() doi 10.1099/jgv.0.000601

Abstract

A new simian retrovirus (SRV) subtype was discovered in China and the U.S. from Cambodian-origin cynomolgus monkeys. Histopathological examination from necropsied animals showed multifocal lymphoplasmacystic and histocytic inflammation. The complete genome sequences demonstrated that the U.S. virus isolates were nearly identical (99.91%-99.93%) and differed only slightly (99.13%-99.16% identical) from the China isolate. Phylogenetic analysis showed that the new virus isolates formed a distinct branch of SRV-1 through -7 and, therefore, were named this subtype SRV-8. This SRV-8 variant was also phylogenetically and serologically more closely related to SRV-4 than any other SRV subtype.

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