Advertisement

 

 

Acute kidney injury in HIV-infected children: comparison of patients according to the use of highly active antiretroviral therapy.

Acute kidney injury in HIV-infected children: comparison of patients according to the use of highly active antiretroviral therapy.
Author Information (click to view)

Soares DS, Cavalcante MG, Ribeiro SM, Leitão RC, Vieira AP, Pires Neto RD, Silva Junior GB, Daher EF,


Soares DS, Cavalcante MG, Ribeiro SM, Leitão RC, Vieira AP, Pires Neto RD, Silva Junior GB, Daher EF, (click to view)

Soares DS, Cavalcante MG, Ribeiro SM, Leitão RC, Vieira AP, Pires Neto RD, Silva Junior GB, Daher EF,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Jornal de pediatria 2016 8 16() pii 10.1016/j.jped.2016.03.009

Abstract
OBJECTIVE
To assess clinical and laboratory data, and acute kidney injury (AKI) in HIV-infected children using and not using highly active antiretroviral therapy (HAART) prior to admission.

METHODS
A retrospective study was conducted with HIV-infected pediatric patients (<16 years). Children who were using and not using HAART prior to admission were compared. RESULTS
Sixty-three patients were included. Mean age was 5.3±4.27 years; 55.6% were females. AKI was observed in 33 (52.3%) children. Patients on HAART presented lower levels of potassium (3.9±0.8 vs. 4.5±0.7mEq/L, p=0.019) and bicarbonate (19.1±4.9 vs. 23.5±2.2mEq/L, p=0.013) and had a higher estimated glomerular filtration rate (102.2±36.7 vs. 77.0±32.8mL/min/1.73m(2), p=0.011) than those not on HAART. In the multivariate analysis, the use of HAART prior to the admission was a protective factor for AKI (p=0.036; OR=0.30; 95% CI=0.097-0.926).

CONCLUSION
AKI is a common complication of pediatric HIV infection. Use of HAART prior to the admission preserved glomerular filtration and was a protective factor for AKI, but increased medication side effects, such as hypokalemia and renal metabolic acidosis.

Submit a Comment

Your email address will not be published. Required fields are marked *

twelve − five =

[ HIDE/SHOW ]