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Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.

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Le Sage V, Cinti A, Amorim R, Mouland AJ,


Le Sage V, Cinti A, Amorim R, Mouland AJ, (click to view)

Le Sage V, Cinti A, Amorim R, Mouland AJ,

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Viruses 2016 05 248(6) doi 10.3390/v8060152

Abstract

The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs.

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