Advertisement

 

 

Adherence to Concurrent Tuberculosis Treatment and Antiretroviral Treatment among Co-Infected Persons in South Africa, 2008-2010.

Adherence to Concurrent Tuberculosis Treatment and Antiretroviral Treatment among Co-Infected Persons in South Africa, 2008-2010.
Author Information (click to view)

Webb Mazinyo E, Kim L, Masuku S, Lancaster JL, Odendaal R, Uys M, Podewils LJ, Van der Walt ML,


Webb Mazinyo E, Kim L, Masuku S, Lancaster JL, Odendaal R, Uys M, Podewils LJ, Van der Walt ML, (click to view)

Webb Mazinyo E, Kim L, Masuku S, Lancaster JL, Odendaal R, Uys M, Podewils LJ, Van der Walt ML,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

PloS one 2016 07 2111(7) e0159317 doi 10.1371/journal.pone.0159317

Abstract
BACKGROUND
Adherence to tuberculosis (TB) treatment and antiretroviral therapy (ART) reduces morbidity and mortality among persons co-infected with TB/HIV. We measured adherence and determined factors associated with non-adherence to concurrent TB treatment and ART among co-infected persons in two provinces in South Africa.

METHODS
A convenience sample of 35 clinics providing integrated TB/HIV care was included due to financial and logistic considerations. Retrospective chart reviews were conducted among persons who received concurrent TB treatment and ART and who had a TB treatment outcome recorded during 1 January 2008-31 December 2010. Adherence to concurrent TB and HIV treatment was defined as: (1) taking ≥80% of TB prescribed doses by directly observed therapy (DOT) as noted in the patient card; and (2) taking >90% ART doses as documented in the ART medical record during the concurrent treatment period (period of time when the patient was prescribed both TB treatment and ART). Risk ratios (RRs) and 95% confidence intervals (CIs) were used to identify factors associated with non-adherence.

RESULTS
Of the 1,252 persons receiving concurrent treatment, 138 (11.0%) were not adherent. Non-adherent persons were more likely to have extrapulmonary TB (RR: 1.71, 95% CI: 1.12 to 2.60) and had not disclosed their HIV status (RR: 1.96, 95% CI: 1.96 to 3.76).

CONCLUSIONS
The majority of persons with TB/HIV were adherent to concurrent treatment. Close monitoring and support of persons with extrapulmonary TB and for persons who have not disclosed their HIV status may further improve adherence to concurrent TB and antiretroviral treatment.

Submit a Comment

Your email address will not be published. Required fields are marked *

15 − 5 =

[ HIDE/SHOW ]