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Aging of the Liver: What This Means for Patients with HIV.

Aging of the Liver: What This Means for Patients with HIV.
Author Information (click to view)

Chan AW, Patel YA, Choi S,


Chan AW, Patel YA, Choi S, (click to view)

Chan AW, Patel YA, Choi S,

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Current HIV/AIDS reports 2016 8 25()

Abstract

As the HIV population continues to live longer as a result of antiretroviral therapy, liver-related mortality has become one of the leading causes of non-AIDS related death in this patient population. The liver possesses a remarkable regenerative capacity but undergoes complex biological changes in response to aging and inflammation that result in decreased cellular regeneration and a tipping of the scales towards fibrogenesis. Patients with HIV infection have serological evidence of ongoing inflammation, with elevations in some biomarkers persisting despite adequate virologic control. In addition, HIV-co-infected patients have markers of advanced age on liver biopsy and increased prevalence of fibrosis as compared to an age-matched HCV mono-infected cohort. In this review, we will discuss the biology of aging, age-related changes in the liver, and the relevant mechanisms by which HIV causes inflammation in the context of accelerated aging, fibrosis of the liver, and other viral co-infection.

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