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American Society for Bone and Mineral Research, Sept. 16-19

American Society for Bone and Mineral Research, Sept. 16-19
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The American Society for Bone and Mineral Research (ASBMR) Annual Meeting

The annual meeting of the American Society for Bone and Mineral Research was held from September 16 to 19 in Atlanta and attracted approximately 4,000 participants from around the world, including basic research scientists and clinical investigators in bone and mineral metabolism, as well as physicians and other health care practitioners. The conference focused on the latest advances in bone and mineral research as well as the translation of research into clinical practice.

In one study, Emmanuel Biver, M.D., Ph.D., of the Geneva University Hospitals in Switzerland, and colleagues found that yogurt consumption is associated with an attenuated cortical bone loss in healthy postmenopausal women, independent of body mass index (BMI), physical activity, and total dietary calcium and protein intakes.

“This suggests a possible protective effect of fermented dairy products on postmenopausal cortical bone loss. The hypotheses to explain this observation are that yogurts may be a marker of healthy lifestyle or may replace potentially harmful foods. They might also have a metabolic effect via a modulation of the gut microbiota,” Biver said. “Additional studies are needed.”

Abstract No. 1112

In another study, Rebekah Harris, P.T., of the University of Pittsburgh, and colleagues found that women with low bone mineral density (BMD) and women with low BMD and sarcopenia tended to be older, white females with a history of falls. In addition, sarcopenia alone was not an independent risk factor for fracture.

“This study was based on the Women’s Health Initiative (WHI). The WHI was started in 1993 and has over 161,000 women from 40 U.S. clinical centers. The women were between 50 and 79 years of age at baseline. We had follow-up for a median of 15.9 years,” Harris said. “The main takeaway from the study is that BMD (as measured by dual-energy X-ray absorptiometry) remains a strong risk factor for fracture. In addition, the combination of BMD and sarcopenia suggest higher risk of hip fracture.”

The increased risk of hip fracture in women appears to be different to that seen in males.

“In men with the combination of sarcopenia and BMD, there was a nearly four times increased risk of any fracture compared to those who did not have either condition. However, in women with sarcopenia and BMD, we found a 1.72-fold increased risk of fracture compared to those who did not have either condition,” Harris said. “There is potential that the loss of lean mass is more pronounced in males than females. There is also potential that the impact of testosterone is more significant on lean mass. Additionally, there may be other processes that impact the quality of muscle in older adults that we are not capturing here.”

Abstract No. 1111

Lisa Langsetmo, Ph.D., of the University of Minnesota in Minneapolis, and colleagues found that increased protein intake in community-dwelling older men was associated with a lower risk of fracture, including hip fracture and other osteoporotic fractures. Specifically, the association depended on the source of the protein. The investigators found that dairy protein and non-dairy animal protein, but not plant protein, were associated with fracture risk.

“Protein intake (animal protein but not plant protein) is a modifiable risk factor for hip fracture and other osteoporotic fractures among older men. Each standard deviation increase in total protein intake (equivalent to one or two additional daily servings of high-protein foods) was associated with a 16 percent lower hip fracture risk and an 8 percent lower osteoporotic fracture risk,” Langsetmo said. “Increased dietary protein intake may be a feasible and low-risk intervention to reduce the risk of hip fracture among older men.”

Abstract No. 1107

ASBMR: Romosozumab Linked to Reduced Fracture Risk

MONDAY, Sept. 19, 2016 (HealthDay News) — For postmenopausal women with osteoporosis, romosozumab is associated with reduced risk of vertebral fracture at 12 months, according to a study published online Sept. 18 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the American Society for Bone and Mineral Research, held from Sept. 16 to 19 in Atlanta.

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