Internal medicine (Tokyo, Japan) 2016 09 1555(18) 2727-30 doi 10.2169/internalmedicine.55.6653
A 27-year-old HIV-infected pregnant Japanese woman was admitted to our hospital at gestational week 14. The patient’s HIV viral load was 71,000 copies/mL, and her CD4 cell count was 147 cells/mm(3). Zidovudine, lamivudine, and lopinavir/ritonavir were administered at gestational week 18. Because the viral load increased to 222,000 copies/mL at the initiation of antiretroviral therapy, we added raltegravir. The decrease in the viral load was satisfactory, and a caesarean delivery was performed. Although the plasma concentration of raltegravir in the neonate was significantly high (2,482 ng/mL), no adverse event was confirmed. There was no evidence of the mother-to-child transmission of HIV.