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An HIV-infected Pregnant Woman Treated with the Long-term Administration of Antiretroviral Therapy Including Raltegravir.

An HIV-infected Pregnant Woman Treated with the Long-term Administration of Antiretroviral Therapy Including Raltegravir.
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Yaita K, Inoue S, Horinouchi T, Kinoshita M, Unno M, Iwata O, Tanaka Y, Gotoh K, Ishibashi M, Sakai Y, Masunaga K, Watanabe H, Tominaga M,


Yaita K, Inoue S, Horinouchi T, Kinoshita M, Unno M, Iwata O, Tanaka Y, Gotoh K, Ishibashi M, Sakai Y, Masunaga K, Watanabe H, Tominaga M, (click to view)

Yaita K, Inoue S, Horinouchi T, Kinoshita M, Unno M, Iwata O, Tanaka Y, Gotoh K, Ishibashi M, Sakai Y, Masunaga K, Watanabe H, Tominaga M,

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Internal medicine (Tokyo, Japan) 2016 09 1555(18) 2727-30 doi 10.2169/internalmedicine.55.6653

Abstract

A 27-year-old HIV-infected pregnant Japanese woman was admitted to our hospital at gestational week 14. The patient’s HIV viral load was 71,000 copies/mL, and her CD4 cell count was 147 cells/mm(3). Zidovudine, lamivudine, and lopinavir/ritonavir were administered at gestational week 18. Because the viral load increased to 222,000 copies/mL at the initiation of antiretroviral therapy, we added raltegravir. The decrease in the viral load was satisfactory, and a caesarean delivery was performed. Although the plasma concentration of raltegravir in the neonate was significantly high (2,482 ng/mL), no adverse event was confirmed. There was no evidence of the mother-to-child transmission of HIV.

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