Advertisement

 

 

APOL1 Renal Risk Variants are Associated with Chronic Kidney Disease in Children and Youth with Perinatal HIV infection.

Author Information (click to view)

Purswani MU, Patel K, Winkler CA, Spector SA, Hazra R, Seage GR, Mofenson L, Karalius B, Scott GB, Van Dyke RB, Kopp JB, ,


Purswani MU, Patel K, Winkler CA, Spector SA, Hazra R, Seage GR, Mofenson L, Karalius B, Scott GB, Van Dyke RB, Kopp JB, , (click to view)

Purswani MU, Patel K, Winkler CA, Spector SA, Hazra R, Seage GR, Mofenson L, Karalius B, Scott GB, Van Dyke RB, Kopp JB, ,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Journal of acquired immune deficiency syndromes (1999) 2016 3 31()

Abstract

APOL1 renal risk alleles are associated with chronic kidney disease (CKD) in adults, with the strongest effect being for HIV-associated nephropathy. Their role in youth with perinatal HIV infection (PHIV) has not been studied. In a nested case-control study of 451 PHIV participants in the Pediatric HIV/AIDS Cohort Study, we found a 3.5-fold increase odds of CKD in those carrying high-risk APOL1 genotypes using a recessive model (95% confidence interval [CI]: 1.2-10.0). We report an unadjusted incidence of 1.2 CKD cases/100 person-years (95% CI: 0.5, 2.5) in PHIV youth carrying APOL1 high-risk genotypes, with important implications for sub-Saharan Africa.

Submit a Comment

Your email address will not be published. Required fields are marked *

five × three =

[ HIDE/SHOW ]