Advertisement

 

 

Assessment of antisperm antibodies in a sample of Egyptian patients with hepatitis C virus infection.

Assessment of antisperm antibodies in a sample of Egyptian patients with hepatitis C virus infection.
Author Information (click to view)

Hussein TM, Elneily D, Eid AA, Abou-ElKhier H,


Hussein TM, Elneily D, Eid AA, Abou-ElKhier H, (click to view)

Hussein TM, Elneily D, Eid AA, Abou-ElKhier H,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Andrologia 2016 8 3() doi 10.1111/and.12664

Abstract

Association of hepatitis C virus (HCV) with autoimmune phenomena and impaired semen parameters has been previously reported. The aim of this study was to investigate the influence of HCV infection on the development of antisperm antibodies (ASAs) in HCV-positive males. The study was conducted on 30 HCV-infected individuals and 30 healthy control subjects. In both patients and control groups, liver enzymes and reproductive hormones were measured; computer-assisted semen analysis (CASA) was performed; HCV-RNA in serum was measured and IgG and IgA ASAs in semen were determined. Free testosterone, sperm concentration, progressive and total motility were significantly lower in HCV patients than in the control group, whereas ASAs of the IgG and IgA classes were significantly higher in HCV patients. However, correlations between viral load and the examined semen parameters and ASAs were nonsignificant. In conclusion, HCV may be responsible for the increased ASAs detected in HCV patients in the present study, possibly providing another plausible explanation for the decreased sperm motility reported in HCV patients. These findings could be of value in fertility management of HCV patients.

Submit a Comment

Your email address will not be published. Required fields are marked *

eleven − 3 =

[ HIDE/SHOW ]