Glycosylphosphatidylinositol-anchored proteins use a unique post-translational modification to link proteins to lipid bilayer membranes. The anchoring structure consists of both a lipid and carbohydrate portion and is highly conserved in eukaryotic organisms regarding its basic characteristics, yet highly variable in its molecular details. The strong membrane targeting property has made the anchors an interesting tool for biotechnological modification of lipid membrane-covered entities from cells through extracellular vesicles to enveloped virus particles. In this review we will take a closer look at the mechanisms and fields of application for GPI anchored proteins in lipid bilayer membrane engineering and discuss their advantages and disadvantages for biomedicine.
Biomedical Applications of Glycosylphosphatidylinositol-anchored Proteins.