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Bone mineral density is associated with left ventricular diastolic function in women.

Bone mineral density is associated with left ventricular diastolic function in women.
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Wang RT, Li XS, Zhang JR, Sun Y, Yu KJ, Liu T,


Wang RT, Li XS, Zhang JR, Sun Y, Yu KJ, Liu T, (click to view)

Wang RT, Li XS, Zhang JR, Sun Y, Yu KJ, Liu T,

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Clinical cardiology 2016 Oct 7() doi 10.1002/clc.22592
Abstract
BACKGROUND
Low bone mineral density (BMD) and left ventricular (LV) diastolic function are associated with heart failure. However, little is known about the association between BMD and LV diastolic function.

HYPOTHESIS
BMD is independently related to LV diastolic function in women.

METHODS
We conducted a cross-sectional study of 432 women. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. LV diastolic function and structure were assessed by echocardiographic examination.

RESULTS
BaPWV and the percentage of LV diastolic dysfunction increased with progressive bone loss. Moreover, partial correlation analysis demonstrated that BMD at spine L2-4 and at femoral neck were correlated with baPWV and LV diastolic function parameters after adjusting covariates. Multivariate logistic regression analysis revealed that osteoporosis was independently associated with LV diastolic dysfunction in women.

CONCLUSIONS
Osteoporosis is independently associated with LV diastolic dysfunction in women. A prospective study is needed to elucidate the effects of BMD on cardiac function in women.

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