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Brief Report: L-Selectin (CD62L) Is Downregulated on CD4+ and CD8+ T Lymphocytes of HIV-1-Infected Individuals Naive for ART.

Brief Report: L-Selectin (CD62L) Is Downregulated on CD4+ and CD8+ T Lymphocytes of HIV-1-Infected Individuals Naive for ART.
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Vassena L, Giuliani E, Buonomini AR, Malagnino V, Andreoni M, Doria M,


Vassena L, Giuliani E, Buonomini AR, Malagnino V, Andreoni M, Doria M, (click to view)

Vassena L, Giuliani E, Buonomini AR, Malagnino V, Andreoni M, Doria M,

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Journal of acquired immune deficiency syndromes (1999) 72(5) 492-7 doi 10.1097/QAI.0000000000000999

Abstract

The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here, we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naive for antiretroviral therapy (ART-naive) or receiving therapy (ART), and seronegative control subjects (HIV-neg). We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naive as compared with ART and HIV-neg groups, particularly within naive and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased after ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared with HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells. We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.

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