Activation of LXRα improves cardiac remodeling induced by pulmonary artery hypertension in rats.

Scientific reports 2017 07 217(1) 6169 doi 10.1038/s41598-017-04640-6 Abstract Inflammatory factors regulated by NF-κB play a significant role in PAH and myocardial hypertrophy. LXR activation may inhibit

High-grade bursal-side partial rotator cuff tears: comparison of mid- and long-term results following arthroscopic repair after conversion to a full-thickness tear.

Journal of orthopaedic surgery and research 2017 07 2112(1) 118 doi 10.1186/s13018-017-0619-7 Abstract BACKGROUND Partial-thickness rotator cuff tears (PTRCTs) are one of the leading causes of shoulder

Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.

Lipids in health and disease 2017 07 2116(1) 139 doi 10.1186/s12944-017-0512-8 Abstract BACKGROUND Recent studies have shown osteocalcin (OC) plays an important role in regulating glucose and

Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS.

PloS one 2017 07 2112(7) e0181863 doi 10.1371/journal.pone.0181863 Abstract BACKGROUND We evaluated the effect of Saccharomyces boulardii CNCM I-745 on intestinal neuromuscular anomalies in an IBS-type mouse

Short-term administration of melatonin or ghrelin on diabetic rats: effects on angiotensin II and vasopressin-induced uterine contractility.

Physiological research 2017 07 18() Abstract The glycosaminoglycan (GAG) molecules are a group of high molecular weight, negatively charged polysaccharides present abundantly in the mammalian organism. By

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes.

Scientific reports 2017 07 207(1) 5998 doi 10.1038/s41598-017-05787-y Abstract Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-producing ß cells which leads to

Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice.

Scientific reports 2017 07 217(1) 6120 doi 10.1038/s41598-017-05040-6 Abstract Nonalcoholic fatty liver disease (NAFLD) in non-obese patients remains a clinical condition with unclear etiology and pathogenesis. Using

National disability-adjusted life years (DALYs) for 257 diseases and injuries in Ethiopia, 1990-2015: findings from the global burden of disease study 2015.

Population health metrics 2017 07 2115(1) 28 doi 10.1186/s12963-017-0146-0 Abstract BACKGROUND Disability-adjusted life years (DALYs) provide a summary measure of health and can be a critical input

Job retention vocational rehabilitation for employed people with inflammatory arthritis (WORK-IA): a feasibility randomized controlled trial.

BMC musculoskeletal disorders 2017 07 2118(1) 315 doi 10.1186/s12891-017-1671-5 Abstract BACKGROUND Inflammatory arthritis leads to work disability, absenteeism and presenteeism (i.e. at-work productivity loss) at high cost

The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.

PloS one 2017 07 2112(7) e0181485 doi 10.1371/journal.pone.0181485 Abstract BACKGROUND The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood

Mechanism of electrocardiographic T-wave flattening in diabetes mellitus: experimental and simulation study.

Physiological research 2017 07 18() Abstract In the present study we investigated the contribution of ventricular repolarization time (RT) dispersion (the maximal difference in RT) and RT

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.

Scientific reports 2017 07 207(1) 5986 doi 10.1038/s41598-017-06236-6 Abstract Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.

Journal of the American Heart Association 2017 07 226(7) pii e005407 Abstract BACKGROUND In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by

The Retinol-Binding Protein Receptor STRA6 Regulates Diurnal Insulin Responses.

The Journal of biological chemistry 2017 07 21() pii jbc.M117.782334 Abstract It has long been appreciated that insulin action is closely tied to circadian rhythms. However, mechanisms

Rubella sero-prevalence among children in Kilimanjaro region: a community based study prior to the introduction of rubella vaccine in Tanzania.

Italian journal of pediatrics 2017 07 2143(1) 63 doi 10.1186/s13052-017-0379-3 Abstract BACKGROUND Childhood rubella infection is a mild, self-limiting illness. Rubella infection among pregnant women however, is

The impact of retirement on age related cognitive decline – a systematic review.

BMC geriatrics 2017 07 2117(1) 160 doi 10.1186/s12877-017-0556-7 Abstract BACKGROUND Knowledge on factors affecting the rate of cognitive decline and how to maintain cognitive functioning in old

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.

PLoS pathogens 2017 07 2113(7) e1006509 doi 10.1371/journal.ppat.1006509 Abstract Latent HIV infection of long-lived cells is a barrier to viral clearance. Hematopoietic stem and progenitor cells are

The effect of hypertension on adult hippocampal neurogenesis in young adult spontaneously hypertensive rats and Dahl rats.

Physiological research 2017 07 18() Abstract The dentate gyrus of the hippocampus is one of the few places in the brain where neurogenesis occurs in adulthood. Nowadays,

An ecological and digital epidemiology analysis on the role of human behavior on the 2014 Chikungunya outbreak in Martinique.

Scientific reports 2017 07 207(1) 5967 doi 10.1038/s41598-017-05957-y Abstract Understanding the spatio-temporal dynamics of endemic infections is of critical importance for a deeper understanding of pathogen transmission,

Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly.

Journal of the American Heart Association 2017 07 226(7) pii e005353 Abstract BACKGROUND Heart failure (HF) and dementia are major causes of disability and death among older

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