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Infectious Disease

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Fate of microglia during HIV-1 infection: From activation to senescence?

Glia 2016 11 26() doi 10.1002/glia.23081 Abstract Microglia support productive human immunodeficiency virus type 1 (HIV-1) infection and disturbed microglial function could contribute to the development of

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The Changing Epidemiology of Human T-Cell Lymphotropic Virus Type 1 Infection in Peruvian Female Sex Workers, 1993-2010.

The American journal of tropical medicine and hygiene 2016 11 22() pii 16-0014 Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to

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The Impact of Viral Suppression and Viral Breakthrough on Limited-Antigen Avidity Assay Results in Individuals with Clade B HIV Infection.

AIDS research and human retroviruses 2016 11 22() Abstract We analyzed the impact of HIV viral load on the performance of a limiting antigen avidity enzyme immunoassay

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Targeting the rhesus macaque TRIM5α gene to enhance the susceptibility of CD4(+) T cells to HIV-1 infection.

Archives of virology 2016 11 25() Abstract The host range of human immunodeficiency virus type 1 (HIV-1) is extremely narrow, which has hampered the establishment of non-human

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Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.

Journal of neurovirology 2016 11 23() Abstract HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This

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Factors that can influence feelings towards and interactions with people living with HIV/AIDS in rural Central Kenya.

International journal of STD & AIDS 2016 11 22() pii 0956462416680764 Abstract BACKGROUND In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural

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Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.

AIDS (London, England) 30(18) 2767-2776 Abstract OBJECTIVE To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide. DESIGN The anti-HIV-1 activity of 5-hydroxytyrosol,

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LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.

Cell reports 17(9) 2221-2233 pii S2211-1247(16)31465-6 Abstract BST2 (bone marrow stromal antigen 2)/tetherin is a restriction factor of enveloped viruses, which blocks the release of viral particles.

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Cellular Senescence, Immunosenescence and HIV.

Interdisciplinary topics in gerontology and geriatrics 2016 11 2242() 28-46 Abstract Aging is a complex biological process that leads to several physiological changes. Among these changes, the

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Chronic lung disease in HIV-infected children established on antiretroviral therapy.

AIDS (London, England) 30(18) 2795-2803 Abstract OBJECTIVE Respiratory disease is a major cause of morbidity and mortality in HIV-infected children. Despite antiretroviral therapy (ART), children suffer chronic

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Activation and Inactivation of Primary Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Journal of virology 2016 11 23() pii JVI.01880-16 Abstract Human immunodeficiency virus (HIV-1) entry into cells is mediated by the viral envelope glycoproteins (Env), a trimer of

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Reassessing APOBEC3G inhibition by HIV-1 Vif-derived peptides.

Journal of molecular biology 2016 11 22() pii S0022-2836(16)30504-6 Abstract The human APOBEC3G (A3G) enzyme restricts HIV-1 in the absence of the viral accessory protein viral infectivity

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Concurrency and HIV transmission network characteristics among MSM with recent HIV infection.

AIDS (London, England) 30(18) 2875-2883 Abstract OBJECTIVE Sexual partner concurrency is common among MSM and may increase the probability of HIV transmission during recent (acute or early)

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Deep sequencing methods for protein engineering and design.

Current opinion in structural biology 2016 11 2245() 36-44 pii S0959-440X(16)30099-9 Abstract The advent of next-generation sequencing (NGS) has revolutionized protein science, and the development of complementary

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Structure based design of cyclically permuted HIV-1 gp120 trimers that elicit neutralizing antibodies.

The Journal of biological chemistry 2016 11 22() pii jbc.M116.725614 Abstract A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly

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Cross-Reactive Potential of HIV-1 Subtype C-Infected Indian Individuals Against Multiple HIV-1 Potential T Cell Epitope Gag Variants.

Viral immunology 2016 11 22() Abstract Vaccine immunogen with expanded T cell coverage for protection against HIV-1 diversity is the need of the hour. This study was

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Effect of HIV infection in the microuclei frequency on the oral mucosa.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 11 22() doi

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Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes.

Scientific reports 2016 11 236() 37489 doi 10.1038/srep37489 Abstract In nature, primate lentiviruses infect humans and several Old World monkeys and apes. However, to date, lentiviruses infecting

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Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile.

Current pharmaceutical design 2016 11 22() Abstract Earlier we reported the identification of diarylpyrimidine-quinolone hybrids as a new class of HIV-1 NNRTIs. A few of these hybrids

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Long-term progression of viral load and serum markers of fibrosis among treated and untreated patients with chronic hepatitis B.

Journal of gastroenterology and hepatology 2016 11 26() doi 10.1111/jgh.13667 Abstract BACKGROUND AND AIMS Antiviral therapy for patients with hepatitis B (HBV) infection is generally deferred for

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