Infectious Disease

Fate of microglia during HIV-1 infection: From activation to senescence?

Glia 2016 11 26() doi 10.1002/glia.23081 Abstract Microglia support productive human immunodeficiency virus type 1 (HIV-1) infection and disturbed microglial function could contribute to the development of

The Changing Epidemiology of Human T-Cell Lymphotropic Virus Type 1 Infection in Peruvian Female Sex Workers, 1993-2010.

The American journal of tropical medicine and hygiene 2016 11 22() pii 16-0014 Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to

The Impact of Viral Suppression and Viral Breakthrough on Limited-Antigen Avidity Assay Results in Individuals with Clade B HIV Infection.

AIDS research and human retroviruses 2016 11 22() Abstract We analyzed the impact of HIV viral load on the performance of a limiting antigen avidity enzyme immunoassay

Targeting the rhesus macaque TRIM5α gene to enhance the susceptibility of CD4(+) T cells to HIV-1 infection.

Archives of virology 2016 11 25() Abstract The host range of human immunodeficiency virus type 1 (HIV-1) is extremely narrow, which has hampered the establishment of non-human

Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.

Journal of neurovirology 2016 11 23() Abstract HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This

Factors that can influence feelings towards and interactions with people living with HIV/AIDS in rural Central Kenya.

International journal of STD & AIDS 2016 11 22() pii 0956462416680764 Abstract BACKGROUND In Kenya, HIV incidence and prevalence have declined. HIV rates are lower in rural

Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.

AIDS (London, England) 30(18) 2767-2776 Abstract OBJECTIVE To investigate the toxicity and activity against HIV of 5-hydroxytyrosol as a potential microbicide. DESIGN The anti-HIV-1 activity of 5-hydroxytyrosol,

LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.

Cell reports 17(9) 2221-2233 pii S2211-1247(16)31465-6 Abstract BST2 (bone marrow stromal antigen 2)/tetherin is a restriction factor of enveloped viruses, which blocks the release of viral particles.

Cellular Senescence, Immunosenescence and HIV.

Interdisciplinary topics in gerontology and geriatrics 2016 11 2242() 28-46 Abstract Aging is a complex biological process that leads to several physiological changes. Among these changes, the

Chronic lung disease in HIV-infected children established on antiretroviral therapy.

AIDS (London, England) 30(18) 2795-2803 Abstract OBJECTIVE Respiratory disease is a major cause of morbidity and mortality in HIV-infected children. Despite antiretroviral therapy (ART), children suffer chronic

Activation and Inactivation of Primary Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Journal of virology 2016 11 23() pii JVI.01880-16 Abstract Human immunodeficiency virus (HIV-1) entry into cells is mediated by the viral envelope glycoproteins (Env), a trimer of

Reassessing APOBEC3G inhibition by HIV-1 Vif-derived peptides.

Journal of molecular biology 2016 11 22() pii S0022-2836(16)30504-6 Abstract The human APOBEC3G (A3G) enzyme restricts HIV-1 in the absence of the viral accessory protein viral infectivity

Concurrency and HIV transmission network characteristics among MSM with recent HIV infection.

AIDS (London, England) 30(18) 2875-2883 Abstract OBJECTIVE Sexual partner concurrency is common among MSM and may increase the probability of HIV transmission during recent (acute or early)

Deep sequencing methods for protein engineering and design.

Current opinion in structural biology 2016 11 2245() 36-44 pii S0959-440X(16)30099-9 Abstract The advent of next-generation sequencing (NGS) has revolutionized protein science, and the development of complementary

Structure based design of cyclically permuted HIV-1 gp120 trimers that elicit neutralizing antibodies.

The Journal of biological chemistry 2016 11 22() pii jbc.M116.725614 Abstract A major goal for HIV-1 vaccine development is an ability to elicit strong and durable broadly

Cross-Reactive Potential of HIV-1 Subtype C-Infected Indian Individuals Against Multiple HIV-1 Potential T Cell Epitope Gag Variants.

Viral immunology 2016 11 22() Abstract Vaccine immunogen with expanded T cell coverage for protection against HIV-1 diversity is the need of the hour. This study was

Effect of HIV infection in the microuclei frequency on the oral mucosa.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 11 22() doi

Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes.

Scientific reports 2016 11 236() 37489 doi 10.1038/srep37489 Abstract In nature, primate lentiviruses infect humans and several Old World monkeys and apes. However, to date, lentiviruses infecting

Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile.

Current pharmaceutical design 2016 11 22() Abstract Earlier we reported the identification of diarylpyrimidine-quinolone hybrids as a new class of HIV-1 NNRTIs. A few of these hybrids

Long-term progression of viral load and serum markers of fibrosis among treated and untreated patients with chronic hepatitis B.

Journal of gastroenterology and hepatology 2016 11 26() doi 10.1111/jgh.13667 Abstract BACKGROUND AND AIMS Antiviral therapy for patients with hepatitis B (HBV) infection is generally deferred for

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