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CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy.

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Judge CJ, Sandberg JK, Funderburg NT, Sherman KE, Butt AA, Kang M, Landay AL, Lederman MM, Anthony DD,


Judge CJ, Sandberg JK, Funderburg NT, Sherman KE, Butt AA, Kang M, Landay AL, Lederman MM, Anthony DD, (click to view)

Judge CJ, Sandberg JK, Funderburg NT, Sherman KE, Butt AA, Kang M, Landay AL, Lederman MM, Anthony DD,

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Journal of acquired immune deficiency syndromes (1999) 2016 6 01()

Abstract

During HIV+HCV+ co-infection CD14CD16-monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF)-specific IFNγ-response, before and during IFNα-treatment. Effector-memory and central-memory CD4-T-cell frequencies were lower in HCV+HIV+ than uninfected-donors, and correlated negatively with HCV-level, CD14CD16-monocytes and plasma sCD14. sCD14 and CD14CD16 monocytes negatively correlated with IFNα-dependent HCV-decline. sCD14 negatively associated with and CD4 effector-memory T-cells positively-associated with CEF-specific IFNγ-response. These data support a role for memory-CD4 T-cells in HCV-containment, and link immune-activation and CD14CD16-monocyte frequency to failure of interferon-dependent HCV-clearance.

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