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Changes in T Cells After ABO-Incompatible Liver Transplantation.

Changes in T Cells After ABO-Incompatible Liver Transplantation.
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Kim JM, Kwon CH, Joh JW, Choi GS, Park JB, Kang ES, Kim SJ, Lee SK,


Kim JM, Kwon CH, Joh JW, Choi GS, Park JB, Kang ES, Kim SJ, Lee SK, (click to view)

Kim JM, Kwon CH, Joh JW, Choi GS, Park JB, Kang ES, Kim SJ, Lee SK,

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Journal of investigative surgery : the official journal of the Academy of Surgical Research 2016 Oct 13() 1-7

Abstract
PURPOSE
T lymphocytes are an essential component of allograft rejection and tolerance. The aims of the present study are to analyze the characteristics of T-cell subsets between ABO-incompatible living donor liver transplantation (ABO-I LDLT) and ABO-compatible LDLT (ABO-C LDLT).

MATERIALS AND METHODS
Between April 2013 and June 2014, 61 patients underwent adult LDLT. ABO-I LDLT patients received rituximab and all patients received basiliximab as induction therapy and tacrolimus as maintenance therapy. The distribution of peripheral blood T lymphocyte subsets pretransplant and 4, 8, 12, and 24 weeks post-transplant were serially monitored.

RESULTS
Eight patients underwent ABO-I LDLT. Patient characteristics did not vary between the ABO-I and ABO-C groups. Absolute lymphocyte counts and CD4+ T cells in the ABO-I group were lower than those in ABO-C group after LDLT (p =.034 and p =.039, respectively). However, the comparison between the ABO-I and ABO-C groups revealed that the CD8+ T cells, CD4/CD8 ratio, Vδ1 cells, Vδ2 cells, γδ T cells, Vδ1/Vδ2 ratio, CD3-CD56+ cells, and CD4+Foxp3+ T cells did not change significantly over time.

CONCLUSIONS
Absolute lymphocyte counts and CD4+ T cell levels are different between ABO-I and ABO-C groups after LDLT. The present study suggests that T-cell lymphocyte changes in peripheral blood in ABO-I LDLT patients were similar to those in ABO-C LDLT patients.

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