Advertisement

 

 

Chronic Binge Alcohol Administration Impairs Glucose-Insulin Dynamics and Decreases Adiponectin in Asymptomatic Simian Immunodeficiency Virus-Infected Macaques.

Chronic Binge Alcohol Administration Impairs Glucose-Insulin Dynamics and Decreases Adiponectin in Asymptomatic Simian Immunodeficiency Virus-Infected Macaques.
Author Information (click to view)

Ford SM, Simon L, Vande Stouwe C, Allerton T, Mercante DE, Byerley LO, Dufour JP, Bagby GJ, Nelson S, Molina PE,


Ford SM, Simon L, Vande Stouwe C, Allerton T, Mercante DE, Byerley LO, Dufour JP, Bagby GJ, Nelson S, Molina PE, (click to view)

Ford SM, Simon L, Vande Stouwe C, Allerton T, Mercante DE, Byerley LO, Dufour JP, Bagby GJ, Nelson S, Molina PE,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

American journal of physiology. Regulatory, integrative and comparative physiology 2016 9 7() ajpregu.00142.2016 doi 10.1152/ajpregu.00142.2016

Abstract

Alcohol use disorders (AUDs) frequently exist among persons living with HIV/AIDS (PLWHA). Chronic alcohol consumption, HIV infection, and anti-retroviral therapy (ART) are independently associated with impairments in glucose-insulin dynamics. Previous studies from our laboratory have shown that chronic binge alcohol (CBA) administration decreases body mass index, attenuates weight gain, and accentuates skeletal muscle wasting at end-stage disease in non-ART treated simian immunodeficiency virus (SIV)-infected male rhesus macaques. The aim of this study was to investigate whether CBA and ART alone or in combination alter body composition or glucose-insulin dynamics in SIV-infected male rhesus macaques during the asymptomatic phase of SIV infection. Daily CBA or sucrose (SUC) administration was initiated 3 mos. prior to intrarectal SIVmac251 inoculation and continued until the study end point at 11 mos. post-SIV infection. ART or placebo was initiated 2.5 months after SIV infection and continued until study end point. Four treatment groups (SUC/SIV±ART and CBA/SIV±ART) were studied. CBA/SIV macaques had a significantly decreased circulating adiponectin and resistin levels relative to SUC/SIV macaques and reduced disposition index (DI), acute insulin response to glucose (AIRg), insulin and C-peptide release during frequently sampled intravenous glucose tolerance test, irrespective of ART status. No statistically significant differences were observed in HOMA-insulin resistance (IR) values, body weight, total body fat, abdominal fat, or total lean mass or bone health among the four groups. These findings demonstrate CBA-mediated impairments in glucose-insulin dynamics and adipokine profile in asymptomatic SIV-infected macaques, irrespective of ART.

Submit a Comment

Your email address will not be published. Required fields are marked *

three × five =

[ HIDE/SHOW ]