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Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitalized for acute lower respiratory tract infection.

Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitalized for acute lower respiratory tract infection.
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Yan XL, Li YN, Tang YJ, Xie ZP, Gao HC, Yang XM, Li YM, Liu LJ, Duan ZJ,


Yan XL, Li YN, Tang YJ, Xie ZP, Gao HC, Yang XM, Li YM, Liu LJ, Duan ZJ, (click to view)

Yan XL, Li YN, Tang YJ, Xie ZP, Gao HC, Yang XM, Li YM, Liu LJ, Duan ZJ,

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Journal of medical virology 2016 9 15() doi 10.1002/jmv.24687

Abstract

Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are two common viral pathogens in acute lower respiratory tract infections (ALRTI). However, the association of viral load with clinical characteristics is not well-defined in ALRTI. To explore the correlation between viral load and clinical characteristics of RSV and HMPV in children hospitalized for ALRTI in Lanzhou, China. 387 children hospitalized for ALRTI were enrolled. Nasopharyngeal aspirates (NPAs) were sampled from each children. Real-time PCR was used to screen RSV, HMPV and twelve additional respiratory viruses. Bronchiolitis was the leading diagnoses both in RSV and HMPV positive patients. A significantly greater frequency of wheezing (52% vs 33.52%, P = 0.000) was noted in RSV positive and negative patients. The RSV viral load was significant higher in children aged

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