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Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults.

Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults.
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Woods AJ, Porges EC, Bryant VE, Seider T, Gongvatana A, Kahler CW, de la Monte S, Monti PM, Cohen RA,


Woods AJ, Porges EC, Bryant VE, Seider T, Gongvatana A, Kahler CW, de la Monte S, Monti PM, Cohen RA, (click to view)

Woods AJ, Porges EC, Bryant VE, Seider T, Gongvatana A, Kahler CW, de la Monte S, Monti PM, Cohen RA,

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Alcoholism, clinical and experimental research 2016 9 22() doi 10.1111/acer.13211

Abstract
BACKGROUND
The acute consumption of excessive quantities of alcohol causes well-recognized neurophysiological and cognitive alterations. As people reach advanced age, they are more prone to cognitive decline. To date, the interaction of current heavy alcohol (ethanol [EtOH]) consumption and aging remains unclear. This study tested the hypothesis that negative consequences of current heavy alcohol consumption on neurocognitive function are worse with advanced age. Further, we evaluated the relations between lifetime history of alcohol dependence and neurocognitive function METHODS: Sixty-six participants underwent a comprehensive neurocognitive battery. Current heavy EtOH drinkers were classified using National Institute on Alcohol Abuse and Alcoholism criteria (EtOH heavy, n = 21) based on the Timeline follow-back and a structured clinical interview and compared to nondrinkers, and moderate drinkers (EtOH low, n = 45). Of the total population, 53.3% had a lifetime history of alcohol dependence. Neurocognitive data were grouped and analyzed relative to global and domain scores assessing: global cognitive function, attention/executive function, learning, memory, motor function, verbal function, and speed of processing.

RESULTS
Heavy current EtOH consumption in older adults was associated with poorer global cognitive function, learning, memory, and motor function (ps < 0.05). Furthermore, lifetime history of alcohol dependence was associated with poorer function in the same neurocognitive domains, in addition to the attention/executive domain, irrespective of age (ps < 0.05). CONCLUSIONS
These data suggest that while heavy current alcohol consumption is associated with significant impairment in a number of neurocognitive domains, history of alcohol dependence, even in the absence of heavy current alcohol use, is associated with lasting negative consequences for neurocognitive function.

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