Smoking, hypertension, hypercholesterolemia, and type 2 diabetes appear to be the cardiovascular (CVD) risk factors mostly associated with development of clinically significant peripheral artery disease (PAD), according to results of a prospective study of nearly 45,000 United States men. At PAD diagnosis, 96% of men had at least one of these CVD risk factors. Among the findings:

Abstract: JAMA, October 24, 2012.