Advertisement

 

 

Differential gene expression in brain and peripheral tissues in depression across the life span: A review of replicated findings.

Differential gene expression in brain and peripheral tissues in depression across the life span: A review of replicated findings.
Author Information (click to view)

Ciobanu LG, Sachdev PS, Trollor JN, Reppermund S, Thalamuthu A, Mather KA, Cohen-Woods S, Baune BT,


Ciobanu LG, Sachdev PS, Trollor JN, Reppermund S, Thalamuthu A, Mather KA, Cohen-Woods S, Baune BT, (click to view)

Ciobanu LG, Sachdev PS, Trollor JN, Reppermund S, Thalamuthu A, Mather KA, Cohen-Woods S, Baune BT,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Neuroscience and biobehavioral reviews 2016 8 23() pii 10.1016/j.neubiorev.2016.08.018

Abstract

There is a growing body of research investigating the gene expression signature of depression at the genome-wide level, with potential for the discovery of novel pathophysiological mechanisms of depression. However, heterogeneity of depression, dynamic nature of gene expression patterns and various sources of noise have resulted in inconsistent findings. We systematically review the current state of transcriptome profiling of depression in the brain and peripheral tissues with a particular focus on replicated findings at the single gene level. By examining 16 brain regions and 5 cell types from the periphery, we identified 57 replicated differentially expressed genes in the brain and 21 in peripheral tissues. Functional overlap between brain and periphery strongly implicates shared pathways in a comorbid phenotype of depression and cardiovascular disease. The findings highlight dermal fibroblasts as a promising experimental model for depression biomarker research, provide partial support for all major theories of depression and suggest a novel candidate gene, PXMP2, which plays a critical role in lipid and reactive oxygen species metabolism.

Submit a Comment

Your email address will not be published. Required fields are marked *

14 + 18 =

[ HIDE/SHOW ]