Advertisement

 

 

Ebola Virus Disease, Democratic Republic of the Congo, 2014.

Ebola Virus Disease, Democratic Republic of the Congo, 2014.
Author Information (click to view)

Nanclares C, Kapetshi J, Lionetto F, de la Rosa O, Tamfun JJ, Alia M, Kobinger G, Bernasconi A,


Nanclares C, Kapetshi J, Lionetto F, de la Rosa O, Tamfun JJ, Alia M, Kobinger G, Bernasconi A, (click to view)

Nanclares C, Kapetshi J, Lionetto F, de la Rosa O, Tamfun JJ, Alia M, Kobinger G, Bernasconi A,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Emerging infectious diseases 22(9) 1579-86 doi 10.3201/eid2209.160354

Abstract

During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 × two =

[ HIDE/SHOW ]