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Effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries.

Effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries.
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Topuz M, Dogan A,


Topuz M, Dogan A, (click to view)

Topuz M, Dogan A,

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Kardiologia polska 2016 Oct 07() doi 10.5603/KP.a2016.0139
Abstract
BACKGROUND
The aim of this study is to evaluate the effect of epicardial adipose tissue (EAT) thickness on left ventricular diastolic functions in patients with normal coronary arteries (NCA) proven by angiography.

METHODS
We selected study patients who were referred to coronary angiography due to typical chest pain or atypical chest pain with a positive pre-test result for coronary artery disease. After coronary angiography, 85 patients had significant coronary lesion (≥50% stenosis) served as coronary artery disease (CAD) group, 82 patients had non-significant coronary lesion (<50% stenosis) and/or a coronary plaque served as non-significant CAD group and 83 patients had normal coronary arteries served as normal coronary artery (NCA) group. All patients were underwent transthoracic echocardiographic (TTE) examination to measure EAT thickness and left ventricular diastolic properties. RESULTS
Gensini score, total cholesterol, and CRP were significantly higher in CAD group compared to non-significant CAD and NCA group. The average of EAT thickness was 7.3 ± 2.4 mm in all groups. It was found as 5.8 ± 2.3 mm in NCA group, 6.4 ± 2.4 mm in non-significant CAD group, and 7.8 ± 2.2 mm in CAD group (p <0.001). In correlation analyses, average of EAT thickness was significantly correlated with E/e' ratio in NCA group. In multivariate analysis, average of EAT thickness was significantly associated with left ventricular diastolic dysfunction (LVDD) in subjects with NCA (OR 1.019, 95% CI 1.012-1.027, p < 0.001). CONCLUSIONS
Based on our findings, EAT thickness may have an effect on left ventricular diastolic functions. This independent relationship showed us the implicating of clinical importance of measuring of EAT thickness.

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