HIV-infected patients demonstrate increased activation of the renin-angiotensin-aldosterone system (RAAS). We evaluated changes in immune markers with physiological RAAS activation.
Immune activation markers were assessed serially in 18 HIV-infected and 7 non-HIV-infected subjects consuming an ad libitum diet followed by a standardized low sodium diet.
CcL-2 (P=0.0004) and sCD163 (P=0.0001) significantly increased with sodium restriction and RAAS activation vs. ad libitum sodium intake among chronically-treated HIV-infected subjects (ART use 11+1 years), but not among non-HIV-infected subjects of similar age and sex.
Dietary sodium restriction, which activates RAAS, uniquely stimulates critical indices of immune activation in HIV.
CLINICAL TRIAL REGISTRATION