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Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices in HIV.

Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices in HIV.
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Srinivasa S, Burdo TH, Williams KC, Mitten EK, Wong K, Fitch KV, Stanley T, Adler GK, Grinspoon SK,


Srinivasa S, Burdo TH, Williams KC, Mitten EK, Wong K, Fitch KV, Stanley T, Adler GK, Grinspoon SK, (click to view)

Srinivasa S, Burdo TH, Williams KC, Mitten EK, Wong K, Fitch KV, Stanley T, Adler GK, Grinspoon SK,

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The Journal of infectious diseases 2016 8 22() pii

Abstract
BACKGROUND
 HIV-infected patients demonstrate increased activation of the renin-angiotensin-aldosterone system (RAAS). We evaluated changes in immune markers with physiological RAAS activation.

METHODS
 Immune activation markers were assessed serially in 18 HIV-infected and 7 non-HIV-infected subjects consuming an ad libitum diet followed by a standardized low sodium diet.

RESULTS
 CcL-2 (P=0.0004) and sCD163 (P=0.0001) significantly increased with sodium restriction and RAAS activation vs. ad libitum sodium intake among chronically-treated HIV-infected subjects (ART use 11+1 years), but not among non-HIV-infected subjects of similar age and sex.

CONCLUSION
 Dietary sodium restriction, which activates RAAS, uniquely stimulates critical indices of immune activation in HIV.

CLINICAL TRIAL REGISTRATION
NCT01407237.

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