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Expression of immunoglobulin-like transcript 4 as an inhibitory receptor in patients with psoriatic arthritis.

Expression of immunoglobulin-like transcript 4 as an inhibitory receptor in patients with psoriatic arthritis.
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Chimenti MS, Bergamini A, Triggianese P, Guarino MD, Gigliucci G, Conigliaro P, Perricone C, Perricone R,


Chimenti MS, Bergamini A, Triggianese P, Guarino MD, Gigliucci G, Conigliaro P, Perricone C, Perricone R, (click to view)

Chimenti MS, Bergamini A, Triggianese P, Guarino MD, Gigliucci G, Conigliaro P, Perricone C, Perricone R,

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The Journal of international medical research 44(1 suppl) 22-27
Abstract
OBJECTIVES
To investigate the presence of immunoglobulin-like transcript (ILT)4 and costimulatory proteins (CD40, CD80 and CD86), as well as tumour necrosis factor (TNF)-α production in antigen-presenting cells (APCs) from patients with psoriatic arthritis, before and after treatment with the antitumour necrosis factor-α therapy, adalimumab.

METHODS
Peripheral blood monocytes from patients with psoriatic arthritis and healthy controls were cultured with CD40 ligand (CD40L) to stimulate differentiation to APCs. Cell-surface phenotype was analysed via fluorescence-activated cell sorting.

RESULTS
CD40L-stimulation resulted in significantly more ILT4(+) monocytes in cultures from control subjects (n = 21) than those from patients (n = 20). ILT4-positivity on CD40L-stimulated monocytes was negatively correlated with disease activity in patients. Adalimumab treatment resulted in significant increases from baseline in ILT4-positivity, and in decreases in CD40, CD80 and CD86-positivity in monocytes from patients.

CONCLUSION
The effect of adalimumab on monocyte surface phenotype may be due to modification of the inflammatory milieu associated with therapy-induced reduction of disease activity in psoriatic arthritis.

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