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Feedback Control of Two-Component Regulatory Systems.

Feedback Control of Two-Component Regulatory Systems.
Author Information (click to view)

Groisman EA,


Groisman EA, (click to view)

Groisman EA,

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Annual review of microbiology 70() 103-24 doi 10.1146/annurev-micro-102215-095331

Abstract

Two-component systems are a dominant form of bacterial signal transduction. The prototypical two-component system consists of a sensor that responds to a specific input(s) by modifying the output of a cognate regulator. Because the output of a two-component system is the amount of phosphorylated regulator, feedback mechanisms may alter the amount of regulator, and/or modify the ability of a sensor or other proteins to alter the phosphorylation state of the regulator. Two-component systems may display intrinsic feedback whereby the amount of phosphorylated regulator changes under constant inducing conditions and without the participation of additional proteins. Feedback control allows a two-component system to achieve particular steady-state levels, to reach a given steady state with distinct dynamics, to express coregulated genes in a given order, and to activate a regulator to different extents, depending on the signal acting on the sensor.

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