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Herpesvirus Respiratory Infections in Immunocompromised Patients: Epidemiology, Management, and Outcomes.

Herpesvirus Respiratory Infections in Immunocompromised Patients: Epidemiology, Management, and Outcomes.
Author Information (click to view)

Reid GE, Lynch JP, Weigt S, Sayah D, Belperio JA, Grim SA, Clark NM,


Reid GE, Lynch JP, Weigt S, Sayah D, Belperio JA, Grim SA, Clark NM, (click to view)

Reid GE, Lynch JP, Weigt S, Sayah D, Belperio JA, Grim SA, Clark NM,

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Seminars in respiratory and critical care medicine 2016 08 0337(4) 603-30 doi 10.1055/s-0036-1584793

Abstract

Among immunocompromised individuals, members of the human Herpesviridae family are frequently encountered pathogens. Cytomegalovirus, herpes simplex virus 1 and 2, varicella zoster virus, Epstein-Barr virus, and human herpesvirus-6, -7, and -8 all establish latency after infection and can reactivate during periods of immunosuppression, leading to both direct and indirect adverse effects on the host including severe organ dysfunction as well as allograft rejection and loss after transplantation. While not all herpesviruses are primary respiratory pathogens, many of their manifestations include involvement of the respiratory tract. This article discusses the individual viruses, their epidemiology, and clinical manifestations as well as recommended treatment and preventive strategies.

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