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Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer.

Human herpesvirus 8 infection contributes to a T helper 2 immune response in men from Tobago with prostate cancer.
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Henning JD, Bonachea LA, Bunker CH, Patrick AL, Jenkins FJ,


Henning JD, Bonachea LA, Bunker CH, Patrick AL, Jenkins FJ, (click to view)

Henning JD, Bonachea LA, Bunker CH, Patrick AL, Jenkins FJ,

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International journal of urology : official journal of the Japanese Urological Association 2016 Oct 12() doi 10.1111/iju.13243

Abstract
OBJECTIVES
To compare the cytokine profile between human herpesvirus 8 seropositive and seronegative men with and without prostate cancer.

METHODS
The study sample was obtained from the Tobago Prostate Survey, an ongoing study of prostate cancer in the Caribbean island of Tobago. Participants in the study were recruited mostly by public service announcement and by word of mouth. For analyses of circulating levels of pro-inflammatory cytokines, participants with biopsy-confirmed prostate cancer (n = 79) were compared with control participants (n = 87).

RESULTS
Cytokine analyses showed a T helper 2 response with suppressed T helper 1 response in prostate cancer patients, as evidenced by significantly increased levels of interleukin-13 and reduced levels of interleukin-12p70. Herpesvirus 8 seropositive men showed significantly increased levels of interleukin-13 and interleukin-10. At logistic regression analyses, interleukin-12p70 predicted prostate cancer in 94.4% of human herpesvirus 8 seropositive men.

CONCLUSIONS
These findings show that prostate cancer elicits an antitumor, T helper 2 response with a suppressed T helper 1 response. Human herpesvirus 8 infection results in a similar immune response supporting the hypothesis that in Tobago, human herpesvirus 8 establishes a chronic infection that can contribute to an immune response favoring the formation and survival of prostate cancer.

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