Advertisement

 

 

Human papillomavirus 16 (HPV16) and HPV52 E6-specific immunity in HIV-infected adults on combination antiretroviral therapy.

Human papillomavirus 16 (HPV16) and HPV52 E6-specific immunity in HIV-infected adults on combination antiretroviral therapy.
Author Information (click to view)

Leng CY, Low HC, Chua LL, Chong ML, Sulaiman H, Azwa I, Roberts JM, Kamarulzaman A, Rajasuriar R, Woo YL,


Leng CY, Low HC, Chua LL, Chong ML, Sulaiman H, Azwa I, Roberts JM, Kamarulzaman A, Rajasuriar R, Woo YL, (click to view)

Leng CY, Low HC, Chua LL, Chong ML, Sulaiman H, Azwa I, Roberts JM, Kamarulzaman A, Rajasuriar R, Woo YL,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

HIV medicine 2016 9 20() doi 10.1111/hiv.12432

Abstract
OBJECTIVES
Human papillomavirus (HPV)-associated cancers disproportionately affect those infected with HIV despite effective combination antiretroviral therapy (cART). The primary aim of this study was to quantify HPV16 and HPV52 E6-specific interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) T-cell responses, a correlate of protective immunity, in the first year following cART initiation and subsequently in those patients with suboptimal (sIR) and optimal (oIR) immune reconstitution.

METHODS
Ninety-four HIV-infected patients were recruited to the study; a longitudinal cohort of patients recruited just prior to commencing cART and followed up for 48 weeks (n = 27), and a cross-sectional cohort (n = 67) consisting of patients with sIR (CD4 T-cell count < 350 cells/μL) and oIR (CD4 T-cell count > 500 cells/μL) after a minimum of 2 years on cART. Controls (n = 29) consisted of HIV-negative individuals. IFN-γ ELISPOT responses against HPV16 and HPV52 E6 were correlated to clinical characteristics, anal and oral HPV carriage, T-cell maturational subsets, markers of activation, senescence and T-regulatory cells.

RESULTS
HPV16 and HPV52 E6-specific T-cell responses were detected in only one of 27 patients (3.7%) during the initial phase of immune recovery. After at least 2 years of cART, those who achieved oIR had significantly higher E6-specific responses (9 of 34; 26.5%) compared with those with sIR (2 of 32; 6.3%) (P = 0.029). Apart from higher CD4 T-cell counts and lower CD4 T-cell activation, no other immunological correlates were associated with the detection of HPV16 and HPV52 E6-specific responses.

CONCLUSIONS
HPV16 and HPV52 E6-specific IFN-γ T-cell responses, a correlate of protective immunity, were detected more frequently among HIV-infected patients who achieved optimal immune recovery on cART (26.5%) compared with those with suboptimal recovery (6.3%).

Submit a Comment

Your email address will not be published. Required fields are marked *

15 + 11 =

[ HIDE/SHOW ]