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IFITMs: Important Factors In Trans-Mission of HIV-1.

IFITMs: Important Factors In Trans-Mission of HIV-1.
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Sauter D, Kirchhoff F,


Sauter D, Kirchhoff F, (click to view)

Sauter D, Kirchhoff F,

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Cell host & microbe 20(4) 407-408 pii 10.1016/j.chom.2016.09.009

Abstract

IFITMs inhibit various enveloped viral pathogens in vitro, but their relevance in vivo has remained unclear. In this issue of Cell Host & Microbe, Foster et al. (2016) show that IFITMs constitute a barrier to HIV-1 transmission and that escape from adaptive immune responses increases viral sensitivity to IFITM restriction.

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