Advertisement

 

 

IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.

IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.
Author Information (click to view)

Tian Y, Mollo SB, Harrington LE, Zajac AJ,


Tian Y, Mollo SB, Harrington LE, Zajac AJ, (click to view)

Tian Y, Mollo SB, Harrington LE, Zajac AJ,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Journal of immunology (Baltimore, Md. : 1950) 2016 07 08197(4) 1308-21 doi 10.4049/jimmunol.1502481

Abstract

T cells provide protective immunity against infections by differentiating into effector cells that contribute to rapid pathogen control and by forming memory populations that survive over time and confer long-term protection. Thus, understanding the factors that regulate the development of effective T cell responses is beneficial for the design of vaccines and immune-based therapies against infectious diseases. Cytokines play important roles in shaping T cell responses, and IL-10 has been shown to modulate the differentiation of CD4 and CD8 T cells. In this study, we report that IL-10 functions in a cell-extrinsic manner early following acute lymphocytic choriomeningitis virus infection to suppress the magnitude of effector Th1 responses as well as the generation of memory CD4 and CD8 T cells. We further demonstrate that the blockade of IL-10 signaling during the priming phase refines the functional quality of memory CD4 and CD8 T cells. This inhibition strategy resulted in a lower frequency of virus-specific follicular Th (Tfh) cells and increased the Th1 to Tfh ratio. Nevertheless, neither germinal center B cells nor lymphocytic choriomeningitis virus-specific Ab levels were influenced by the blockade. Thus, our studies show that IL-10 influences the balance between Th1 and Tfh cell differentiation and negatively regulates the development of functionally mature memory T cells.

Submit a Comment

Your email address will not be published. Required fields are marked *

four − 4 =

[ HIDE/SHOW ]