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Immune complexes that contain HIV antigens activate peripheral blood T cells.

Immune complexes that contain HIV antigens activate peripheral blood T cells.
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Korolevskaya LB, Shmagel KV, Saidakova EV, Shmagel NG, Chereshnev VA,


Korolevskaya LB, Shmagel KV, Saidakova EV, Shmagel NG, Chereshnev VA, (click to view)

Korolevskaya LB, Shmagel KV, Saidakova EV, Shmagel NG, Chereshnev VA,

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Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian 2016 09 07469(1) 196-8 doi 10.1134/S0012496616040062

Abstract

Uninfected donor T cells were treated in vitro by model immune complexes that contained either HIV or hepatitis C virus (HCV) antigens. Unlike HCV antigen-containing complexes, the immune complexes that contained HIV antigens have been shown to activate peripheral blood T cells of uninfected donors under in vitro conditions. Both the antiviral antibodies and HIV antigen were involved in the activation process. The unique properties of the immune complexes formed by HIV antigens and antiviral antibodies are believed to result from the virus-specific antibody properties and molecular conformation of the antigen-antibody complex.

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