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Impact of HIV-1 subtypes on AIDS progression in a Brazilian cohort.

Impact of HIV-1 subtypes on AIDS progression in a Brazilian cohort.
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Leite TC, Campos DP, Coelho AB, Teixeira SL, Veloso VG, Morgado MG, Guimarães ML,


Leite TC, Campos DP, Coelho AB, Teixeira SL, Veloso VG, Morgado MG, Guimarães ML, (click to view)

Leite TC, Campos DP, Coelho AB, Teixeira SL, Veloso VG, Morgado MG, Guimarães ML,

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AIDS research and human retroviruses 2016 7 15()

Abstract

Viral and host factors are known to play a role in the different patterns of AIDS progression. The co-circulation of HIV-1 subtypes B, F1, BBR and BF1; the occasional detection of HIV-1 subtype D; and an increasing prevalence of subtype C and other recombinant forms have been described in Rio de Janeiro, Brazil. The aim of this study was to evaluate the potential association of HIV-1 subtypes circulating among HIV-1+ individuals in Rio de Janeiro with AIDS disease progression. For this purpose, 246 HIV-1+ individuals under clinical and laboratory follow-up from 1986 to 2011 were classified according to their progression to AIDS as typical progressors (TPs; n=133), rapid progressors (RPs; n=95) or long-term non-progressors (LTNPs; n=18). The env-gp120 region was amplified and sequenced. Neighbor Joining phylogenetic inferences were performed in Mega 6, and bootscan analysis was performed in Simplot 3.5.1. The Kaplan-Meier method and Cox modeling were performed to determine the time until an AIDS-defining event based on the HIV-1 subtypes/variants. Similar AIDS progression rates were observed among the individuals infected with HIV-1 subtype B and variant BBR. However, a direct association between more rapid AIDS progression and HIV-1 subtypes D and BF1 was confirmed in the multivariate analysis, corroborating previous results. Our findings contribute to the investigation of the possible influence of HIV-1 subtypes in AIDS outcome.

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