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Infections in moderate-to-severe psoriasis patients treated with biological drugs compared to classic systemic drugs: Findings from the BIOBADADERM registry.

Infections in moderate-to-severe psoriasis patients treated with biological drugs compared to classic systemic drugs: Findings from the BIOBADADERM registry.
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Dávila-Seijo P, Dauden E, Descalzo MA, Carretero G, Carrascosa JM, Vanaclocha F, Gómez-García FJ, De la Cueva-Dobao P, Herrera-Ceballos E, Belinchón I, López-Estebaranz JL, Alsina M, Sánchez-Carazo JL, Ferrán M, Torrado R, Ferrandiz C, Rivera R, Llamas M, Jiménez-Puya R, García-Doval I, ,


Dávila-Seijo P, Dauden E, Descalzo MA, Carretero G, Carrascosa JM, Vanaclocha F, Gómez-García FJ, De la Cueva-Dobao P, Herrera-Ceballos E, Belinchón I, López-Estebaranz JL, Alsina M, Sánchez-Carazo JL, Ferrán M, Torrado R, Ferrandiz C, Rivera R, Llamas M, Jiménez-Puya R, García-Doval I, , (click to view)

Dávila-Seijo P, Dauden E, Descalzo MA, Carretero G, Carrascosa JM, Vanaclocha F, Gómez-García FJ, De la Cueva-Dobao P, Herrera-Ceballos E, Belinchón I, López-Estebaranz JL, Alsina M, Sánchez-Carazo JL, Ferrán M, Torrado R, Ferrandiz C, Rivera R, Llamas M, Jiménez-Puya R, García-Doval I, ,

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The Journal of investigative dermatology 2016 9 24() pii S0022-202X(16)32459-9
Abstract

Information regarding the safety of biological drugs prescribed to psoriasis patients on daily and long-term bases is insufficient. We used data from the BIOBADADERM registry (Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases) to generate crude rates of infection during therapy with systemic drugs, including biological drugs (infliximab, etanercept, adalimumab, and ustekinumab) and non-biological drugs (acitretin, cyclosporine, and methotrexate). We also calculated unadjusted and adjusted risk ratios (RR) (with propensity score adjustment) of infection, serious infections, and recurrent infections of systemic therapies compared with methotrexate, using Poisson regression. Our study included records of 2153 patients (7867.5 person-years). The adjusted RR of overall infection was significantly increased in the groups treated with adalimumab with methotrexate [adjusted RR=2.13 (95% CI: 1.2-3.7)], infliximab [1.71 (95% CI: 1.1-2.65)], cyclosporine [1.58 (95% CI: 1.17-2.15)], ustekinumab with methotrexate [1.56 (95% CI: 1.08-2.25)], and etanercept [1.34 (95% CI: 1.02-1.76)] compared with methotrexate alone. Cyclosporine had a significant risk of serious infection [adjusted RR=3.12 (95% CI: 1.1-8.8)], followed by adalimumab combined with methotrexate [adjusted RR=3.28 (95% CI: 0.8-13.5)]. Adalimumab in combination with methotrexate had the highest risk of infection recurrence [adjusted RR=4.33 (95% CI: 2.27-8.24)].

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