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M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner.

M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner.
Author Information (click to view)

Wang Q, Zhang X, Han Y, Wang X, Gao G,


Wang Q, Zhang X, Han Y, Wang X, Gao G, (click to view)

Wang Q, Zhang X, Han Y, Wang X, Gao G,

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Scientific reports 2016 09 086() 32736 doi 10.1038/srep32736

Abstract

M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virion production. We provide evidence showing that M2BP inhibits HIV-1 Gag trafficking to the plasma membrane in a vimentin-dependent manner. When vimentin filaments were collapsed by treating cells with acrylamide or by overexpression of a dominant-negative mutant of vimentin, M2BP inhibition of HIV-1 virion production was significantly relieved. We further show that M2BP interacts with both HIV-1 Gag and vimentin and thereby mediates their interactions. We propose that M2BP traps HIV-1 Gag to vimentin filaments to inhibit the transportation of HIV-1 Gag to the plasma membrane. These findings uncover a novel mechanism by which a host antiviral factor inhibits HIV-1 virion production.

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