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Misclassification of Antiretroviral Treatment Failure Using WHO 2006 and 2010/2013 Immunologic Criteria in HIV-Infected Children and Adolescents in Western Kenya.

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Dufort EM, DeLong AK, Mann M, Nyandiko WM, Ayaya SO, Hogan JW, Kantor R,


Dufort EM, DeLong AK, Mann M, Nyandiko WM, Ayaya SO, Hogan JW, Kantor R, (click to view)

Dufort EM, DeLong AK, Mann M, Nyandiko WM, Ayaya SO, Hogan JW, Kantor R,

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Journal of the Pediatric Infectious Diseases Society 2016 4 29() pii

Abstract

We evaluated treatment failure misclassification in human immunodeficiency virus-infected Kenyan children whose targeted viral loads were determined after suspected immunologic/clinical failure according to 2006 and 2010/2013 World Health Organization guidelines. The misclassification rate was 21% for the 2006 guidelines and 46% for the 2010/2013 guidelines, which supports current recommendations for routine viral load monitoring but not necessarily the proposed CD4 thresholds.

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