Advertisement

 

 

Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).

Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).
Author Information (click to view)

Gianotti N, Galli L, Maserati R, Sighinolfi L, Ripamonti D, Palvarini L, Lo Caputo S, Focà E, Celesia BM, Baldelli F, Sterrantino G, Lazzarin A,


Gianotti N, Galli L, Maserati R, Sighinolfi L, Ripamonti D, Palvarini L, Lo Caputo S, Focà E, Celesia BM, Baldelli F, Sterrantino G, Lazzarin A, (click to view)

Gianotti N, Galli L, Maserati R, Sighinolfi L, Ripamonti D, Palvarini L, Lo Caputo S, Focà E, Celesia BM, Baldelli F, Sterrantino G, Lazzarin A,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

The new microbiologica 2016 8 2339(3)

Abstract

In a multicentre, open-label, clinical trial, 43 patients virologically suppressed while receiving a standard triple antiretroviral therapy were randomized (1:1:1) to switch to monotherapy with darunavir/ritonavir (DRV/r-MT arm), monotherapy with lopinavir/ritonavir (LPV/r-MT arm) or to continue on the ongoing regimen (cART arm). The proportion (95% CI) of patients with virological success (Snapshot analysis) at week 48 was 73% (48%-90%) in the DRV/r-MT arm, 69% (42%-88%) in the LPV/r-MT arm and 87% (61%-98%) in the cART arm. Virological failure was detected in only one patient receiving LPV/r-MT. The LPV/r-MT arm showed a modest worsening in lipid profile.

Submit a Comment

Your email address will not be published. Required fields are marked *

18 − 3 =

[ HIDE/SHOW ]