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Near Full-Length Genome Sequences of Two Novel HIV-1 Recombinant Forms Detected In Henan Province, China.

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Li T, Sun G, Jia D, Sun C, Wang Z, Liu S, Liu Y, Li H, Wang X, Li J, Li L,


Li T, Sun G, Jia D, Sun C, Wang Z, Liu S, Liu Y, Li H, Wang X, Li J, Li L, (click to view)

Li T, Sun G, Jia D, Sun C, Wang Z, Liu S, Liu Y, Li H, Wang X, Li J, Li L,

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AIDS research and human retroviruses 2016 4 14()

Abstract

In recent years, the population who was infected through sex contact has seen the fastest growing prevalence of HIV transmission in Henan province, China. Here we report 2 novel HIV-1 recombinant form detected from a comprehensive HIV-1 molecular epidemiologic study among heterosexuals. Recombinant analyses of the near full-length genome of the two novel HIV-1 recombinant isolates: 01B.CN.2012.11092’s backbone of the genome was CRF01_AE, and 414bp of subtype B’ (from 4482 to 4896 according to the HXB2 calibrator) .01BC.CN.2011.11312 was composed of 3 segments (CRF01_AE/CRF_07BC /B’) with breakpoints 4274 and 4833 according to the HXB2 calibrator. They are different from previously identified recombinant strains reported in China. The identification of the unique recombinant forms indicated further complication of the HIV epidemic in Henan and the urgent need for epidemiological surveillance of the new recombination.

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