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Neurodegeneration and RNA-binding proteins.

Neurodegeneration and RNA-binding proteins.
Author Information (click to view)

De Conti L, Baralle M, Buratti E,


De Conti L, Baralle M, Buratti E, (click to view)

De Conti L, Baralle M, Buratti E,

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Wiley interdisciplinary reviews. RNA 2016 9 22() doi 10.1002/wrna.1394

Abstract

In the eukaryotic nucleus, RNA-binding proteins (RBPs) play a very important role in the life cycle of both coding and noncoding RNAs. As soon as they are transcribed, in fact, all RNA molecules within a cell are bound by distinct sets of RBPs that have the task of regulating its correct processing, transport, stability, and function/translation up to its final degradation. These tasks are particularly important in cells that have a complex RNA metabolism, such as neurons. Not surprisingly, therefore, recent findings have shown that the misregulation of genes involved in RNA metabolism or the autophagy/proteasome pathway plays an important role in the onset and progression of several neurodegenerative diseases. In this article, we aim to review the recent advances that link neurodegenerative processes and RBP proteins. For further resources related to this article, please visit the WIREs website.

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