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Novel approaches in preclinical HIV vaccine research.

Novel approaches in preclinical HIV vaccine research.
Author Information (click to view)

Safrit JT, Koff WC,


Safrit JT, Koff WC, (click to view)

Safrit JT, Koff WC,

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Current opinion in HIV and AIDS 2016 9 15()

Abstract
PURPOSE OF REVIEW
The purpose is to review recent novel approaches in HIV vaccine research and development being undertaken in the preclinical and early clinical space, as well as related and novel nonvaccine approaches such as genetic delivery of broadly neutralizing antibodies for protection from HIV infection and AIDS.

RECENT FINDINGS
We review novel HIV envelope immunogen design, including native trimer and germline targeting approaches as well as genetic delivery of broadly neutralizing antibodies and replicating vector vaccines SUMMARY: Despite 30+ years of research and development, and billions of dollars spent, a well tolerated and effective HIV vaccine remains a public health priority for any chance of ending the AIDS pandemic. It has become very clear that significant investments in novel technologies, innovation, and multidisciplinary science will be necessary to accelerate progress.

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