Influenza and other respiratory viruses 2016 7 21() doi 10.1111/irv.12415
This manuscript describes the identification of an oseltamivir resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir resistant strain, combined with a partial immune reconstitution was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient. This article is protected by copyright. All rights reserved.