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Piezotronic Effect Enhanced Label-Free Detection of DNA Using a Schottky-Contacted ZnO Nanowire Biosensor.

Piezotronic Effect Enhanced Label-Free Detection of DNA Using a Schottky-Contacted ZnO Nanowire Biosensor.
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Cao X, Cao X, Guo H, Li T, Jie Y, Wang N, Wang ZL,


Cao X, Cao X, Guo H, Li T, Jie Y, Wang N, Wang ZL, (click to view)

Cao X, Cao X, Guo H, Li T, Jie Y, Wang N, Wang ZL,

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ACS nano 2016 08 0310(8) 8038-44 doi 10.1021/acsnano.6b04121

Abstract

A sensitive and in situ selective label-free DNA sensor based on a Schottky-contacted ZnO nanowire (NW) device has been developed and utilized to detect the human immunodeficiency virus 1 gene in this work. Piezotronic effect on the performance of the DNA sensor is studied by measuring its output current under different compressive strains and target complementary DNA concentrations. By applying a -0.59% compressive strain to a ZnO NW-based DNA sensor, the relative current response is greatly enhanced by 454%. A theoretical model is proposed to explain the observed behaviors of the DNA sensor. This study provides a piezotronically modified method to effectively improve the overall performance of the Schottky-contacted ZnO NW-based DNA sensor.

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