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PLA Micro- and Nano-Particles.

Author Information (click to view)

Lee BK, Yun Y, Park K,


Lee BK, Yun Y, Park K, (click to view)

Lee BK, Yun Y, Park K,

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Advanced drug delivery reviews 2016 6 1() pii 10.1016/j.addr.2016.05.020

Abstract

Poly(D,L-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anti-cancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations.

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