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Plasmatic NT-proBNP concentrations in patients with coexistent periodontal disease and congestive heart failure – pilot studies.

Plasmatic NT-proBNP concentrations in patients with coexistent periodontal disease and congestive heart failure – pilot studies.
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Czerniuk MR, Bartoszewicz Z, Filipiak KJ, Dudzik-Niewiadomska I, Pilecki T, Górska R,


Czerniuk MR, Bartoszewicz Z, Filipiak KJ, Dudzik-Niewiadomska I, Pilecki T, Górska R, (click to view)

Czerniuk MR, Bartoszewicz Z, Filipiak KJ, Dudzik-Niewiadomska I, Pilecki T, Górska R,

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Kardiologia polska 2016 Oct 07() doi 10.5603/KP.a2016.0148
Abstract
BACKGROUND
Presented pilot study was conducted in order to evaluate dynamic fluctuations of blood inflammation markers among patients with congestive heart failure (CHF) and coexistent periodontitis (PDis).

AIM
Study hypothesis stated that elimination of chronic inflammation caused by PDis has a significant impact on inflammation markers and, secondarily, also on course and prognosis of CHF. NT-proBNP and TNF-alpha markers were assessed due to their proven diagnostic significance.

METHODS
Blood samples were collected at the time of CHF patients admission to the clinical ward (I examination) and then after 3-9 months (6 months) after periodontal treatment completion (II examination). With antibiotic cover basic periodontal parameters such as CAL, PD, PI, BOP were evaluated, scaling and root-planing were performed and OPG X-rays were conducted. Patients received instructions about domestic oral hygiene procedures. Measurements were repeated during second examination of blood samples. Obtained results were compared and statistically analyzed.

RESULTS
Initial outcome of the study confirmed hypothesis that maintaining good and complex oral hygiene has an essential impact on blood concentration of NT-proBNP and TNF-alpha markers.

CONCLUSIONS
Exploration of possibilities considering medical help and treatment optimization seems to be evident also according to improvement of prognosis, therapy effectiveness and patient comfort. Foregoing conclusions about biomarkers are, according to authors best knowledge, first such results reported in medical literature.

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