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Randomized Factorial Trial of Phone-Delivered Support Counseling and Daily Text Message Reminders for HIV Treatment Adherence.

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Kalichman SC, Kalichman MO, Cherry C, Eaton LA, Cruess D, Schinazi RF,


Kalichman SC, Kalichman MO, Cherry C, Eaton LA, Cruess D, Schinazi RF, (click to view)

Kalichman SC, Kalichman MO, Cherry C, Eaton LA, Cruess D, Schinazi RF,

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Journal of acquired immune deficiency syndromes (1999) 2016 4 21()

Abstract
BACKGROUND
HIV infection is clinically managed with antiretroviral therapy (ART), but only with sustained adherence. Cost-efficient interventions to improve and sustain ART adherence remain a pressing priority for populations challenged by non-adherence.

PURPOSE
To test the independent and interactive effects of (a) brief phone-delivered self-regulation counseling and (b) daily phone-delivered text message medication reminders on HIV adherence and HIV viral suppression.

METHOD
A randomized 2 (5-sessions of phone-delivered adherence support counseling vs. contact-matched control) x 2 (daily ART text reminders vs. no reminders) trial with primary endpoints of monthly phone-based unannounced pill count-determined ART adherence and HIV viral suppression monitored over 12-months.

RESULTS
Self-regulation adherence counseling demonstrated significant improvements in achieving 90% ART adherence relative to the control group over the first 6-months of follow-up. Effects remained significant in sensitivity analyses conducted at 85% and 95% adherence. Counseling also demonstrated modest but significant effects on HIV suppression. There were no main effects or interactions for daily text message reminders, with some evidence for adverse effects on adherence self-efficacy.

CONCLUSIONS
Brief adherence support counseling delivered by phone demonstrates clinically meaningful improvements in ART adherence and HIV suppression, although these benefits were not evidenced in all patients or in the long-term. Advancing adherence interventions along with an effective means for sustaining gains in adherence remain priorities if ART is to achieve its potential clinical and public health benefits.

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