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Role of HHV-8 and mTOR pathway in post-transplant Kaposi sarcoma staging.

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Hernández-Sierra A, Rovira J, Petit A, Moya-Rull D, Mazuecos MA, Sánchez-Fructuoso AI, Errasti P, Idoate MÁ, Cruzado JM, Vidal A, Diekmann F, Oppenheimer F, Campistol JM, Revuelta I,


Hernández-Sierra A, Rovira J, Petit A, Moya-Rull D, Mazuecos MA, Sánchez-Fructuoso AI, Errasti P, Idoate MÁ, Cruzado JM, Vidal A, Diekmann F, Oppenheimer F, Campistol JM, Revuelta I, (click to view)

Hernández-Sierra A, Rovira J, Petit A, Moya-Rull D, Mazuecos MA, Sánchez-Fructuoso AI, Errasti P, Idoate MÁ, Cruzado JM, Vidal A, Diekmann F, Oppenheimer F, Campistol JM, Revuelta I,

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Transplant international : official journal of the European Society for Organ Transplantation 2016 5 21() doi 10.1111/tri.12800

Abstract

Kaposi’s sarcoma (KS) is one of the most frequent transplant related tumors. Several pathways are involved; however, the impact of the molecular phenotype associated to the tumor stage and the behavior-depending resultant therapy are still unknown. The aim of our study was to analyze the role of HHV-8 and mTOR pathway in tumor stages of skin KS after renal transplantation. Twelve renal transplant recipients with cutaneous KS from five transplant centers (1980-2007) under reduction of immunosuppression or conversion to mTOR inhibitor were included. The expression of HHV-8, PTEN, TGFβ, VEGF, phospho-mTOR and phospho-P70S6K in tumoral tissue was analyzed. KS lesions were classified as patch, plaque and nodule state. HHV-8 infection was found in all tissue samples. KS lesions showed high activation of VEGF, p-mTOR and p-P70S6K, low PTEN, and null TGFβ expression. The only pathway activated in a staging dependent manner was mTOR with higher p-mTOR and p-P70S6K expression in nodule versus patch stage. KS lesions disappeared after 5.24 months in all converted patients without any recurrence in 14.05 years of mean follow-up. The activation of mTOR pathway according to KS stages supports the rational of the mTOR inhibitor in posttransplant Kaposi. This article is protected by copyright. All rights reserved.

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