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Spatial genome organization and cognition.

Spatial genome organization and cognition.
Author Information (click to view)

Rajarajan P, Gil SE, Brennand KJ, Akbarian S,


Rajarajan P, Gil SE, Brennand KJ, Akbarian S, (click to view)

Rajarajan P, Gil SE, Brennand KJ, Akbarian S,

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Nature reviews. Neuroscience 2016 Oct 06() doi 10.1038/nrn.2016.124

Abstract

Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal ‘3D genome’ could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition.

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