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Synthesis and polymerase incorporation of β,γ-modified α-l-threofuranosyl thymine triphosphate mimics.

Synthesis and polymerase incorporation of β,γ-modified α-l-threofuranosyl thymine triphosphate mimics.
Author Information (click to view)

Chen Z, Meek KN, Rangel AE, Heemstra JM,


Chen Z, Meek KN, Rangel AE, Heemstra JM, (click to view)

Chen Z, Meek KN, Rangel AE, Heemstra JM,

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Bioorganic & medicinal chemistry letters 2016 07 0426(16) 3958-62 doi 10.1016/j.bmcl.2016.07.008

Abstract

Three β,γ-modified α-l-threofuranosyl nucleoside triphosphates were synthesized. The β,γ-modified tTTPs undergo a single incorporation event with HIV RT but undergo multiple incorporations to form full-length product with engineered thermophilic polymerases.

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