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Diabetes & Fracture Hospitalization Risk

Diabetes & Fracture Hospitalization Risk

Published research has indicated that people with type 2 diabetes are at increased risk for bone fractures. The link between diabetes and fracture risk, however, has historically depended upon the location of the fracture being investigated. Few large, community-based studies of fracture risk have explored possible associations of diagnosed diabetes, undiagnosed diabetes, and fracture risk. “The risk of fracture-related hospitalizations was higher among adults with diagnosed diabetes than those without the disease.” In an effort to fill the void in available research, my colleagues and I conducted a study that compared the risk of fracture-related hospitalization in people without diabetes to those with diagnosed and undiagnosed diabetes. We also examined associations of diabetes medication use and chronic hyperglycemia with fracture risk. Our study—published in Diabetes Care—used data from the NIH-funded Atherosclerosis Risk in Communities Study, a community-based population. Diabetes Increases Risks Results from our investigation showed that the risk of fracture-related hospitalizations was higher among adults with diagnosed diabetes than those without the disease. The risk of fracture-related hospitalization was nearly twice as high for people with diagnosed diabetes. These findings remained even after adjusting for important risk factors, such as age, sex, BMI, physical activity, and smoking. Conversely, fracture risk was similar between people with undiagnosed diabetes and those without the disease. Importantly, our analysis also revealed that fracture risk was higher in people with diagnosed diabetes who were treated with insulin. The risk was also higher in those with A1C levels of 8% or higher when compared with those who had A1Cs lower than 8%. The associations of diagnosed diabetes and fracture risk did not differ by...
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