Conference Highlights: CROI 2012

CROI 2012, the annual Conference on Retroviruses and Opportunistic Infections, took place from March 5-8 in Seattle. The features below highlight just some of the studies that emerged from the conference. Can Circumcision Decrease Herpes Risk? Deferred Vs Immediate ART in Children Reducing Risk in Partners of HIV-Positive Individuals Monthly HIV Prophylaxis Appears Promising Sustaining Virologic Responses in HIV-HCV Coinfection Can Circumcision Decrease Herpes Risk? The Particulars: Previous research has shown that males who undergo circumcision can help reduce their risk of contracting HIV infection. Less is known about additional long-term effects of circumcision with regard to the transmission of other infectious diseases. Data Breakdown: Investigators conducted a study of men in a South African town before and after a roll-out of a circumcision project. The prevalence of circumcision increased from 15.6% to 49.4% among those aged 15 to 49. The prevalence of herpes simplex virus-2 (HSV-2) among uncircumcised men was 30.8%, compared with 17.1% among circumcised men. Circumcision led to a 27.0% reduction in the risk of acquiring HSV-2. Take Home Pearl:Circumcision appears to reduce the risk of contracting HIV infection and also significantly reduces the likelihood of contracting HSV-2 among recipients of the procedure. [back to top] Deferred Vs Immediate ART in Children The Particulars: Immediate antiretroviral therapy (ART) during infancy has been shown to benefit HIV-infected babies. However, this treatment strategy may put HIV-infected babies at risk for drug side effects and resistance to available treatments, among other potential concerns. Data Breakdown: A study of infants who received immediate ART found that those who stopped treatment after 1 to 2 years appeared to fare significantly better...